3/10/2024 0 Comments Blastopore dorsal lip![]() Dorsal leading edge cells will form structures of the head. In addition, the leading edge cells have moved all the way to the anterior region of the embryo. The dorsal IMZ cells produce the axial mesoderm including notochord and somites. Also note that by the end of this process, the deep cells of the original marginal zone have spread to create a new middle layer of tissue within the embryo, the mesoderm. This results in preferential elongation of the embryo along the forming anterior-posterior axis. (3) Convergence and extension is highly asymmetric the dorsal IMZ cells (shown on the left here) converge and extend much more dramatically than the ventral and lateral regions of the IMZ. Rudolf Winklbauer, Mesoderm and endoderm internalization in the Xenopus gastrula,, 10.1016/bs.ctdb.2019.09.002, (2019). If you look at the Figure 4 fate map, you will notice that the dorsal mesoderm (the mesoderm at the dorsal lip of the blastopore) will become the notochord. The observations suggest that neuroectodermal PCP is not instructed by a preexisting molecular gradient, but induced by a signal from the dorsal blastopore lip, which is likely the source of the PCP-instructing signal for the Xenopus neural plate. Number of times cited according to CrossRef: 11. In particular, you need to think about the dorsal lip of the blastopore, the place where involution first begins and happens most extensively. (2) The deep cells of the involuting marginal zone (shown in red here), then move into the interior via involution, as they undergo convergence and extension. A role for the dorsal lip of the blastopore as the organizer is discussed in relation to the origin of the notochord. The sequence can be divided into several steps: (1) As the dorsal lip of the blastopore forms, leading edge mesoderm (shown in orange here) is rotated up into the interior of the embryo as "tongue" of material, probably as result of the apical constriction and bending of the blastopore lip by bottle cells. Gastrulation in Xenopus: Deep Fate MapThe animated sequence below provides an overview of the deep cells of the marginal zone during gastrulation in Xenopus. For fibronectin quantification, a rectangle 25 m wide and 100 m long was drawn at a distance of 300 m from the dorsal blastopore lip () across the cleft of Brachet (red-boxed area).
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